Sébastien Talbot, Ph.D.
Tenured Associate Professor 2022-
Department of Biomedical and Molecular Sciences. Queen’s University
My laboratory integrates neuroscience and immunology, which is a novel and highly dynamic field, and combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. My goal is to identify the mechanisms and molecules that regulate the interplay between the immune and sensory nervous systems in physiology and pathology. Among the others, I will investigate: 1) the capacity of nociceptors to sense allergens, 2) the role of nociceptor neurons in cancer immunosurveillance, and 3) how nociceptors control fibrosis.
Tier-2 Canada Research Chair, Chair in Neuro-Immunology 2017-2022
Assistant Professor, Université de Montréal. 2017-2022
Faculty of Medicine. Dept of Pharmacology and Physiology.
RESEARCH FUNDING
Total funding: $ 9,537,000 2017-2028
Operating: $ 8,497,000
Equipment: $ 1,040,000
Research Initiation Grant. (150,000$) 2022-2026
Queen’s University
PI. Sebastien Talbot
Project Grant. (925,650$) 2021-2026
ATF3+ tumor-innervating neurons control anti-cancer immunity.
Canadian Institutes of Health Research (CIHR)
PI. Sebastien Talbot
Grant # 461275
Project Grant. (925,650$) 2021-2026
FcεR1+ nociceptor neurons control type-1 hypersensitivity reaction.
Canadian Institutes of Health Research (CIHR)
PI. Sebastien Talbot
Grant # 461274
Project Grant. (765,000$) 2019-2024
Nociceptor neurons drive cancer immunosurveillance.
Canadian Institutes of Health Research
PI. Sebastien Talbot. Co-PI. Manu Rangachari (U Laval)
Grant # 162211
Discovery Grant. (160,000$) 2019-2024
Deciphering the nervous and immune systems dialogue
Natural Sciences and Engineering Research Council of Canada (NSERC)
PI. Sebastien Talbot.
Grant # DGECR/00457-2019 and Grant # RGPIN/06824-2019
Industry research contract. (16,000$) 2022-2023
Silencing sensory neurons to rescue anti-tumor immunity
Nocion Therapeutics, Cambridge, MA
PI. Sebastien Talbot.
Operating Grant. (165,000$) 2021-2023
Tumor-innervating neurons control anti-cancer immunity.
Mitacs Accélération
PI. Sebastien Talbot.
Grant # IT27113-Talbot-Cygnal Therapeutics
Operating Grant. (120,000$) 2021-2023
Tumor-innervating PDL1+ neurons block cancer immunosurveillance.
Cancer Research Society (CRS)
PI. Sebastien Talbot. CoPI. Jacques Thibodeau, Sonia Del Rincon.
Grant # 840775
Tier-2 Canada Research Chair. Neuro-Immunology (500,000$) 2017-2022
Canadian Institutes of Health Research
PI. Sebastien Talbot.
Grant # 950-231859
Emerging project grant. (75,000$) 2021-2022
Silencing sensory neurons to resolve SARS-CoV-2 inflammation
UdeM – Combattre la COVID-19 : de la prévention au contrôle
PI. Sebastien Talbot. Co-PI. May Griffith
Operating grant. 2021-2022
Microglia drives Parkinson’s disease-induced painful neuropathy.
Fonds de Recherche Sante Quebec (FRQS)
Centre interdisciplinaire de recherche sur le cerveau et l’apprentissage (CIRCA)
PI. Sebastien Talbot (6,000$)
Co-PI. Louis-Eric Trudeau (0$). Janelle Drouin-Ouellet (34,000$)
Industry research contract. (185,000$) 2021-2022
Tumor-innervating nociceptor neurons control pDC activity
Cygnal Therapeutics, Cambridge, MA
PI. Sebastien Talbot.
Industry research contract. (65,000$) 2021-2022
Silencing sensory neurons to resolve SARS-CoV-2 inflammation
Nocion Therapeutics, Cambridge, MA
PI. Sebastien Talbot. CoPI. May Griffith
Canada Foundation for Innovation, (415,000$) 2017-2022
John R. Evans Leaders fund
PI. Sebastien Talbot.
Grant # 37439.
Industry research contract. (140,000$) 2020-2021
Target identification of neuronal involvement in B16F10 tumor growth
Cygnal Therapeutics, Cambridge, MA
PI. Sebastien Talbot.
Operating grant. (100,000$) 2019-2021
Nociceptor neurons control cancer immunosurveillance
Brain Canada/Azrieli foundation
PI. Sebastien Talbot
Start-up fund, Merck Canada (365,000$) 2017-2020
Université de Montréal
PI. Sebastien Talbot.
Research Project (R01) grant 2023-2028
Cancer brain circuit affects behavior
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
PI. Paola Vermeer (1,500,000$),
CoPI. Sebastien Talbot (400,000$), Geoffroy Laumet (400,000$)
Grant # R01
Research Center. 2019-2023
Centre Interdisciplinaire de Recherche sur le Cerveau et l’Apprentissage (CIRCA)
Fonds de recherche du Québec- Santé,
PI. Chirstian Casanova (1,600,000$)
Co-PI. Sebastien Talbot and 58 others.
Equipment Grant. 2022
Sound-Induced 3D Bio-fabrication and Morphogenesis
Natural Sciences and Engineering Research Council of Canada (NSERC)
PI. Houman Savoki (128,000$)
Co-PI: Sebastien Talbot (0$), May Griffith, Noel Raynal, Nicolas Dumont
Grant # RTI-2022-00539
New Frontiers in Research Fund - Exploration, 2019-2021
Nanophotonics-controlled silencing of nociceptor neurons
New Frontiers in Research Fund
PI. Christos Boutopoulos (125,000$)
Co-PI: Sebastien Talbot (125,000$)
Grant # NFRFE-2019-01326
Equipment Grant. 2020
A Seahorse analyzer for the multiparametric study of cellular metabolism in prokaryotes and eukaryotes.
Natural Sciences and Engineering Research Council of Canada (NSERC)
PI. Jacques Thibodeau (250,000$)
Co-PI: Sebastien Talbot (0$), Louis-Éric Trudeau, Moutih Rafei, France Daigle, Marylise Duperthuy, Janelle Drouin-Ouellet, Guy Lemay, Simon-Pierre Gravel
Grant # OIR2020
CAPES PRiNT. 2019
Promote the construction and consolidation of strategic plans for the internationalization of institutions, to stimulate the formation of research networks and mobility of researchers
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
PI : Alexendra Latini.
Co-PI. Sebastien Talbot (0$)
EDUCATION
Ph. D. in Physiology, Université de Montréal, Canada 2006-2012
Thesis title: Localization, induction mechanism and pathophysiological role of kinin B1 receptor in experimental model of pain in the rat.
B. Sc. in Pharmacology, Université de Sherbrooke, Canada 2003-2006
PREVIOUS RESEARCH EXPERIENCE
Postdoctoral training, Boston Children’s Hospital, USA 2012-2017
Mentor: Dr Clifford J. Woolf. Harvard Medical School. Dept. of Neurobiology
Main focus: Development of mice models of nociceptor ablated mice and validation of pharmacological compounds (charged voltage gated sodium channel blocker and charged calcium channel blocker) to specifically silence pain neurons subjected to inflammation. Highlight the importance of nociceptors as key drivers of allergic airway inflammation.
Internship, Pontifical Catholic University of Rio Grande do Sul, Brazil 2011-2012
Mentor: Dr Maria Martha Campos. Dept. of Pharmacology
Main focus: Validate the use of kinin B1 receptor knockout mice in diabetic pain neuropathy. Highlight the key role of kinin B1 receptor in diabetic pain-induced microgliosis.
Graduate studies, Université de Montréal, Canada 2006-2012
Mentor: Dr Réjean Couture. Dept. of Pharmacology and Physiology
Main focus: Development of a fluorescent agonist to specifically localize kinin B1 receptor in the rat CNS. Validation of a kinin B1 receptor non-peptidic and selective antagonists in a rat model of diabetic pain neuropathy. Establish a rat 3D lung primary culture cell method to assess lung inflammation and fibrosis when exposed to cigarette smoke. Unravelling the mechanism of induction, the cellular localization and pathophysiological role of kinin B1 receptor in experimental rat models of pain and inflammation.
FELLOWSHIPS
Postdoctoral fellowship, Canadian Institutes of Health Research (CIHR) 2014-2017
Postdoctoral fellowship, Fonds Recherche en Santé du Québec (FRQS) 2012-2014
“Timely completion of Ph.D. studies” Scholarship 2012
Université de Montréal (UdeM)
Michael Smith Foreign Study Supplement, CIHR 2011-2012
Ph. D. fellowship, CIHR 2009-2012
Frederick Banting and Charles Best Canada graduate scholarship
Ph. D. fellowship, FRQS 2008-2009
Fellowship for accelerated passage to the Ph.D, UdeM 2007-2009
M. Sc. fellowship, FRQS 2008-2009
Undergraduate internship scholarship, FRQS 2005
B. Sc. excellence scholarship 2003-2006
Association des Universités et Collèges du Canada
AWARDS
Effervescence Star (1,000$) 2021
Gilead Sciences and Montreal invivo
PI: Sebastien Talbot
CAPES PRiNT – Visiting professor (16,000$) 2020
Promote the construction and consolidation of strategic plans for the internationalization of institutions, to stimulate the formation of research networks and mobility of researchers
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
PI: Sebastien Talbot
Young Investigator Award Competition – short listed 2018
The International Union of Basic and Clinical Pharmacology (IUPHAR)
World Congress of Basic and Clinical Pharmacology0
Featured in the June 2018 issue of "Pharmacology International"
World Health Organization - Invited as KOL 2018
World Health Organization’s Collaborating Centre on Population Health Research and Training in Edinburgh, The National Institute for Health Research UK (NIHR) RESPIRE Global Health Unit, Centre for Global Health Research at the University of Edinburgh
Web of Science’s citation metrics identified me as the lead author of the highly cited paper on Asthma
Invited as KOL to set research priorities for Asthma globally over the next 10 years
Best poster presentation (€ 200) 2018
European Academy of Allergy and Clinical Immunology, Munich, Germany
Technology development fund award, Boston Children’s hospital 2016
Dean’s Honor list (PhD thesis), Université de Montréal 2012
Thesis defense ranked in the top 5% of the year, Université de Montréal 2012
Nomination Jacques Genest best presentation award (100$) 2011
Club de Recherches Cliniques du Québec
Awards for excellence in PhD studies, Université de Montréal (15,000$) 2008-2010
Jacques Genest best presentation award (500$) 2008
Club de Recherches Cliniques du Québec
The General Governor’s medal, Government of Canada. 1999-2000